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‚PDƒŒƒgƒƒgƒ‰ƒ“ƒXƒ|ƒ]ƒ“i‚k‚h‚m‚dj‚Ì“]ˆÚ‹@\‚̉𖾂Ɖž—p

iŒ¤‹†‚Ì”wŒij

2003”N‚ɃqƒgƒQƒmƒ€‚̉ð“Ç‚ª‚قڏI—¹‚µAŒ¤‹†ŽÒ‚Ì‘½‚­‚̓Qƒmƒ€‚Ì50“‚ð‚àè‚ß‚é—˜“Iˆâ“`Žqiselfish genesj‚Ì–c‘傳‚É‚ ‚炽‚ß‚Ä‹Á‚©‚³‚ê‚Ü‚µ‚½B“Á‚ɁALINEilong interspersed nuclear elementj‚ƌĂ΂ê‚é“]ˆÚˆöŽq‚́A‚»‚Ì”¼”ˆÈã‚ðè‚߁AŒ»Ý‚àŠˆ”­‚É“]ˆÚ‚ðŒJ‚è•Ô‚µA‚ ‚éŽí‚̈â“`•a‚âƒKƒ“‚ÌŒ´ˆö‚Æ‚È‚Á‚Ä‚¢‚é‚Æ‚¢‚í‚ê‚Ü‚·BLINE‚͐³Ž®‚É‚Ínon-LTRŒ^ƒŒƒgƒƒgƒ‰ƒ“ƒXƒ|ƒ]ƒ“‚ƌĂсAƒGƒCƒYƒEƒBƒ‹ƒX‚Ȃǂ̃ŒƒgƒƒEƒBƒ‹ƒX‚â‚»‚ê‚É‹ß‚¢LTRŒ^ƒŒƒgƒƒgƒ‰ƒ“ƒXƒ|ƒ]ƒ“‚æ‚è‚ài‰»“I‚Ɍ¢‚ƍl‚¦‚ç‚ê‚Ü‚·i}‚PŽQÆjB‹t“]ŽÊ‚É‚æ‚Á‚ăQƒmƒ€‚É“ü‚荞‚Þ“]ˆÚˆöŽq‚𑍏̂µ‚ăŒƒgƒˆöŽq‚ƌĂт܂·‚ªAƒŒƒgƒƒEƒBƒ‹ƒX‚É‹ß‚¢LTRŒ^‚ÌŒ¤‹†‚ªi‚Þˆê•û‚ŁALINE‚ɂ‚¢‚ẮA‚¢‚Ü‚¾‚É‚»‚Ì“]ˆÚ•û–@‚·‚ç–¾Šm‚É‚³‚ê‚Ä‚¢‚Ü‚¹‚ñB@ƒŒƒgƒˆöŽq‚́Aˆâ“`Žq“±“ü‚Å•p”É‚É—˜—p‚³‚êA‹@”\‰ð–¾‚̐i‚ñ‚Å‚¢‚éDNAŒ^‚̃gƒ‰ƒ“ƒXƒ|ƒ]ƒ“iƒVƒ‡ƒEƒWƒ‡ƒEƒoƒG‚Ì‚ˆöŽq‚Ȃǁj‚Æ‚Í‹NŒ¹‚ð‘S‚­ˆÙ‚Æ‚·‚é‚à‚Ì‚Å‚·B

LINE‚́AƒqƒgƒQƒmƒ€‚ÉŒÀ‚炸‚Ù‚Ú‘S‚Ă̐^Šj×–E‚É‘¶Ý‚µA¶•¨Žíiƒqƒg‚âƒJƒCƒRj‚É‚æ‚Á‚Ă̓Qƒmƒ€‚Ì10“ˆÈã‚ðè‚߁AƒQƒmƒ€i‰»‚ðŒê‚éã‚ÅŒ‡‚©‚¹‚È‚¢‚à‚Ì‚Å‚·B“]ˆÚ‚É‚ ‚½‚Á‚āA•ÏˆÙEŒ‡Ž¸E‹tˆÊ‚È‚Ç‚ðˆø‚«‹N‚±‚·ˆê•ûAƒvƒƒ‚[ƒ^[‚âƒGƒ“ƒnƒ“ƒT[A“Á’è‚Ì‹@”\ƒhƒƒCƒ“—̈æ‚ÌŽ‚¿ž‚݁Aprocessed pseudogene‚ÌŒ`¬‚ȂǁAˆâ“`Žq‚Ì‹@”\i‰»‚É‚àd—v‚È“­‚«‚ð‰Ê‚½‚µ‚Ä‚«‚Ü‚µ‚½BLINE‚Í’P‚È‚é–ï‰îŽÒ‚Å‚Í‚È‚­AƒQƒmƒ€Ä\’z‚É‘å‚«‚È–ðŠ„‚ð‰Ê‚½‚µ‚Ä‚«‚½Œ÷˜JŽÒ‚Å‚ ‚é‚Æ‚à‚¢‚¦‚Ü‚·B‚µ‚©‚µALINE‚Ì“]ˆÚƒƒJƒjƒYƒ€‚Ì’mŽ¯‚Ì•s‘«‚ªŒ¤‹†‚Ì–W‚°‚Æ‚È‚Á‚Ä‚¢‚Ü‚·BŽ„‚½‚¿‚ÌŒ¤‹†‚Ì–Ú•W‚̈ê‚‚́A©’Ž‚Ƀ†ƒj[ƒN‚È‚¢‚­‚‚©‚ÌLINE‚ð—p‚¢‚āALINE‚Ì“]ˆÚƒƒJƒjƒYƒ€‚ðŠ®‘S‚ɉ𖾂·‚邱‚Æ‚Å‚·B

ƒeƒƒƒ‰[ƒ[‚ÌŠˆ«‚ª‹É‚ß‚Ä’á‚¢ƒŒƒxƒ‹‚É—}‚¦‚ç‚ê‚Ä‚¢‚éƒJƒCƒRi€–Ú‚Q‚ðŽQÆ‚­‚¾‚³‚¢j‚ł́AƒeƒƒƒA”½•œ”z—ñ‚ð•W“I‚É‚µ‚½SART, TRAS‚Æ‚¢‚¤“ÁŽê‚Ènon-LTRŒ^ƒŒƒgƒƒgƒ‰ƒ“ƒXƒ|ƒ]ƒ“‚ªŠˆ”­‚É“]ˆÚ‚µ‚Ä‚¢‚Ü‚·BŽ„‚½‚¿‚Í‚±‚̃eƒƒƒA—̈æ‚É“ÁˆÙ“I‚É‘}“ü‚·‚郌ƒgƒƒ|ƒ]ƒ“‚â‚’‚c‚m‚`‚É‚Ì‚Ý“]ˆÚ‚·‚郌ƒgƒƒgƒ‰ƒ“ƒXƒ|ƒ]ƒ“iR1, R2j‚ð—˜—p‚µ‚āALINE‚Ì“]ˆÚƒƒJƒjƒYƒ€‚ðŠ®‘S‚ɉ𖾂µ‚½‚¢‚ƍl‚¦‚Ä‚¢‚Ü‚·B‚»‚Ì‚½‚ß‚ÌŽè–@‚Æ‚µ‚āAŠj‘½Šp‘̃EƒBƒ‹ƒX(AcNPV)‚É‚±‚ê‚ç‚̃Œƒgƒƒgƒ‰ƒ“ƒXƒ|ƒ]ƒ“‚ð‘g‚ݍž‚݁AŠ´õ‚É‚æ‚èƒQƒmƒ€“à‚Ì“Á’è‚̏ꏊ‚É“]ˆÚ‚³‚¹APCR–@‚É‚æ‚èŒø—¦“I‚É“]ˆÚ‚ðŒŸo‚·‚é•û–@‚ðŠJ”­‚µ‚Ü‚µ‚½Bi‰º}ŽQÆjiŽQl•¶Œ£jOkazaki et al. (1995, 1997), Takahashi & Fujiwara (2002), Kawashima et al. (2007), Osanai-Futahashi & Fujiwara (2011).

@‚±‚Ì•û–@‚ð—p‚¢‚é‚ƁALINE‚̂ǂ̂悤‚ȗ̈æ‚É“]ˆÚ‚É•K{‚È‹@”\‚ª‰B‚³‚ê‚Ä‚¢‚é‚Ì‚©‚ð”äŠr“I—eˆÕ‚É’²‚ׂ邱‚Æ‚ª‚Å‚«‚Ü‚·BŒ»ÝA‚±‚̂悤‚È‹@”\‚ª”äŠr“I‰ðÍ‚³‚ê‚Ä‚¢‚é‚̂̓qƒg‚ÌL‚P‚Æ‚¢‚¤ƒŒƒgƒƒgƒ‰ƒ“ƒXƒ|ƒ]ƒ“‚Å‚·‚ªAŽ„‚½‚¿‚ÌŽÀŒ±Œn‚ł́A‚±‚ê‚Ü‚Å’m‚ç‚ê‚Ä‚¢‚È‚¢”X‚ÌLINE‚Ì‹@”\—̈æ‚𖾂炩‚É‚µ‚Ä‚«‚Ü‚µ‚½B‰º‚̐}‚́A“–Œ¤‹†Žº‚ª–¾Šm‚É‚µ‚½AƒeƒƒƒA“ÁˆÙ“ILINE‚ÌSART1‚̍\‘¢‚Æ‹@”\—̈æ‚ÌŠT—ª‚ðŽ¦‚µ‚Ä‚¢‚Ü‚·B

iŒ»Ýs‚Á‚Ä‚¢‚錤‹†‚ÌŠT—ªj

i‚`j@LINE‚ÌORF1ƒ^ƒ“ƒpƒNŽ¿‚Ì‹@”\‚Æ“K‰ží—ªF@‘½‚­‚ÌLINE‚Í“ñ‚‚ÌORF (Open reading frame)‚©‚ç\¬‚³‚ê‚Ä‚¢‚Ü‚·‚ªAORF2‚ª‹t“]ŽÊy‘f‚È‚Ç“]ˆÚ‚É•K{‚È‹@”\ƒhƒƒCƒ“‚ðŽ‚Á‚Ä‚¢‚é‚̂ɑ΂µAORF1‚Ì‹@”\‚Í‚Ù‚Æ‚ñ‚Ç’m‚ç‚ê‚Ä‚¢‚Ü‚¹‚ñBSART1‚ÌORF1‚Ì‹@”\ƒhƒƒCƒ“‚ð–Ô—…“I‚É’²‚ׂ½Œ‹‰ÊAORF1‚Ì’†‚ɂ́AV‹K‚ÈŠjˆÚsƒVƒOƒiƒ‹AƒeƒƒƒA‚ÉŒ‹‡‚·‚é—̈æAƒ^ƒ“ƒpƒNŽ¿‘ŠŒÝì—p‚ÉŠÖ‚í‚Á‚Ä‚¢‚é—̈æ‚È‚Ç‚ª–¾‚ç‚©‚É‚È‚è‚Ü‚µ‚½B‚±‚̂悤‚È‹@”\‚́AƒzƒXƒg‚̈â“`Žq‚ւ̉e‹¿‚ðÅ¬ŒÀ‚É—¯‚߂ăeƒƒƒA‚¾‚¯‚É“]ˆÚ‚µ‚ăRƒs[‚ðŠg‘å‚·‚éA‚Æ‚¢‚¤“K‰ží—ª‚ð‰Â”\‚É‚µ‚Ä‚¢‚é‚ƍl‚¦‚ç‚ê‚Ü‚·B—lX‚ÈLINE‚ÌORF1‚ªŒÂX‚̃‰ƒCƒtƒTƒCƒNƒ‹‚É‚ ‚Á‚½“K‰ž“I‹@”\‚ð•t‰Á‚µ‚Ä‚¢‚é‚Æ‚·‚ê‚΋»–¡[‚¢‚±‚Æ‚Å‚·BiŽQl•¶Œ£jMatsumoto T. et al. (2004), Matsumoto T. et al. (2006), Osanai-Futahashi & Fujiwara (2011).

i‚ajLINE‚Ì‹t“]ŽÊ‹@\‚̉𖾁F@LINE‚́AƒŒƒgƒƒEƒBƒ‹ƒX‚ɋ߉‚ÈLTRŒ^ƒŒƒgƒƒgƒ‰ƒ“ƒXƒ|ƒ]ƒ“‚ª×–EŽ¿‚Å‹t“]ŽÊ‚ð‹N‚±‚µ“]ˆÚ‚·‚é‚̂Ƃ͈قȂèAŠj‚ÌDNA‚𒼐ڕW“I‚Æ‚µ‚Đؒf‚µA‚»‚±‚Å‹t“]ŽÊ‚ð‹N‚±‚µ‚Ä“]ˆÚ‚µ‚Ü‚·B‚±‚̃ƒJƒjƒYƒ€‚ðTPRTitarget primed reverse transcriptionj‚ƌĂсAƒeƒƒƒ‰[ƒ[‚È‚Ç‚àŽ—‚½ƒƒJƒjƒYƒ€‚ðŽ‚Á‚Ä‚¢‚Ü‚·B‚µ‚©‚µATPRT‚ª‚ǂ̂悤‚ȃvƒƒZƒX‚ÅŽn‚Ü‚èAis‚·‚é‚Ì‚©‚Í‚Ü‚¾‚æ‚­‚í‚©‚Á‚Ä‚¢‚Ü‚¹‚ñB‚ǂ̂悤‚ȃ^ƒ“ƒpƒNŽ¿-‚q‚m‚`•¡‡‘Ì‚ª“]ˆÚƒ†ƒjƒbƒg‚ðŒ`¬‚µAŠj‚â•W“I‚c‚m‚`‚ւǂ̂悤‚ɃAƒNƒZƒX‚·‚é‚Ì‚©H‚c‚m‚`‚̐ؒf‚͂ǂ̂悤‚É‚µ‚Ä‹N‚±‚èA‹t“]ŽÊ‚͂ǂ̂悤‚ÉŽn‚Ü‚èis‚·‚é‚Ì‚©H‚È‚Ç‚Ì‹^–₪‚ ‚è‚Ü‚·Bƒ^ƒ“ƒpƒNŽ¿|RNA|DNAŠÔ‚Ì•¡ŽG‚È‘ŠŒÝì—p‚ª—\‘z‚³‚ê‚Ü‚·‚ªA‚»‚̉𖾂̓ŒƒgƒˆöŽq‚Ì“®‘ԁEi‰»‚âƒQƒmƒ€Ä\’z‚È‚Ç‚Ì—‰ð‚É‘å‚«‚ȃCƒ“ƒpƒNƒg‚ð—^‚¦‚é‚ÆŠú‘Ò‚µ‚Ä‚¢‚Ü‚·BiŽQl•¶Œ£jOsanai et al. (2004), Anzai et al. (2005), Osanai-Futahashi & Fujiwara (2011), Nichuguti et al. (2016).

iCjˆâ“`Žq“±“üƒxƒNƒ^[‚Æ‚µ‚Ä‚ÌLINE‚Ì—˜—pF—˜ŒÈ“Iˆâ“`Žq‚Ì‘½‚­‚̓gƒ‰ƒ“ƒXƒWƒFƒjƒbƒNŒÂ‘̂̍쐬‚Ì‚½‚߂̃xƒNƒ^[‚Æ‚µ‚čL‚­Žg‚í‚ê‚Ä‚«‚Ü‚µ‚½B‚µ‚©‚µALINE‚Í‚»‚Ì“]ˆÚƒƒJƒjƒYƒ€‚ª•s–¾‚Å‚ ‚邽‚߁A‚±‚ê‚Ü‚Å‚Ù‚Æ‚ñ‚ÇŽg‚í‚ê‚邱‚Æ‚Í‚ ‚è‚Ü‚¹‚ñ‚Å‚µ‚½BŽ„‚½‚¿‚ÍŠj‘½Šp‘̃EƒBƒ‹ƒX‚É‚æ‚èƒeƒƒƒA“ÁˆÙ“ILINE‚ð©’Ž×–E“à‚Å”­Œ»‚³‚¹AƒeƒƒƒA—̈æ‚É“]ˆÚ‚³‚¹‚邱‚Ƃɐ¬Œ÷‚µ‚Ü‚µ‚½BLINE‚Í‚Ù‚Æ‚ñ‚Ç‚·‚ׂĂ̐^Šj×–E‚É‘¶Ý‚·‚é‚̂ŁA“¯—l‚Ì•û–@‚ª—˜—p‚Å‚«‚é‚Ì‚Å‚Í‚È‚¢‚©‚ƍl‚¦A‘¼‚̍©’Ž‚â‹›—ނȂǍL”͂Ȑ¶•¨‚ÉLINE‚ð—p‚¢‚Ĉâ“`Žq‚ðŒø—¦“I‚É“±“ü‚·‚éŽè–@‚ðŒ¤‹†‚µ‚Ä‚¢‚Ü‚·B‚Ü‚½A•”ˆÊ“ÁˆÙ“ILINE‚ð—p‚¢‚é‚ƏhŽå‚̈â“`Žq‚ð”j‰ó‚·‚邱‚Æ‚È‚­ŠO—ˆˆâ“`Žq‚ðˆÀ‘S‚É“±“ü‚·‚邱‚Æ‚ª‚Å‚«‚é‚悤‚É‚È‚è‚Ü‚·B‚±‚ê‚Í“Á‚Ƀqƒg‚̈â“`ŽqŽ¡—ÂȂǂŊ뜜‚³‚ê‚Ä‚¢‚é–â‘è‚ð‰ñ”ð‚·‚é‚±‚Ƃɖ𗧂¿‚Ü‚·BŽ„‚½‚¿‚̓qƒg×–E‚ð—p‚¢‚ăQƒmƒ€‚Ì“Á’è—̈æ‚É“ü‚éˆâ“`Žq“±“üƒxƒNƒ^[‚ÌŠJ”­‚ðs‚Á‚Ä‚¢‚Ü‚·BiŽQl•¶Œ£jTakahashi & Fujiwara (2002), Kawashima et al. (2007), Fujiwara (2015).

iŽQl•¶Œ£E‘àˆê——j@ã‹LŒ¤‹†‚É“Á‚ÉŠÖŒW‚̐[‚¢‚à‚͉̂©F‚ÅŽ¦‚µ‚½

1)         Fujiwara, H., Ogura, T., Takada, N., Miyajima, N., Ishikawa, H. and Maekawa, H.: Introns and their flanking sequences of Bombyx mori rDNA. Nucleic Acids Res. (1984) 12, 6861-6869.

2)         Fujiwara, H., Ninaki, O., Kobayashi, M., Kusuda, J. and Maekawa, H.: Chromosomal fragment responsible for genetic mosaicism in larval body marking of the silkworm, Bombyx mori. Genet. Res. (1991) 57, 11-16.

3)         Okazaki, S., Tsuchida, K., Maekawa, H., Ishikawa, H. and Fujiwara, H.: Identification of a pentanucleotide telomeric sequence, (TTAGG)n, in the silkworm, Bombyx mori and in other insects. Mol. Cell. Biol. (1993) 13, 1424-1432.

4)         Fujiwara, H., Yanagawa, M. and Ishikawa, H.: Mosaic formation by developmental loss of chromosomal fragment in a genetic mosaic, mottled striped of the silkworm, Bombyx mori. Roux's Arch. Dev. Biol. (1994) 203, 389-396.

5)         Fujiwara, H. and Maekawa, H.: RFLP analysis of chromosomal fragments in mottled striped strains of the silkworm, Bombyx mori. Chromosoma (1994) 103, 468-474.

6)         Okazaki, S., Ishikawa, H. and Fujiwara, H: Structural analysis of TRAS1, a novel family of telomeric repeat associated retrotransposons in the silkworm, Bombyx mori. Mol. Cell. Biol. (1995) 15, 4545-4552.

7)         Takahashi, H., Okazaki, S. and Fujiwara, H.: A new family of site-specific retrotransposons, SART1, is inserted into telomeric repeats of the silkworm, Bombyx mori.. Nucleic Acids Res. (1997) 25, 1578-1584.

8)         Takahashi, H. and Fujiwara, H.: Transcription analysis of the telomeric repeat-specific retrotransposons TRAS1 and SART1 of the silkworm Bombyx mori. Nucleic Acids Res. (1999) 27, 2015-2021.

9)         Sasaki, T. and Fujiwara, H.: Detection and distribution patterns of telomerase activity in insects. Eur. J. Biochem. (2000) 267, 3025-3031.

10)     Fujiwara, H., Nakazato, Y., Okazaki, S. and Ninaki, O.: Stability and telomere structure of chromosomal fragments in two different mosaic strains of the silkworm, Bombyx mori. Zool Sci. (2000) 17, 743-750.

11)     Anzai, T., Takahashi, H. and Fujiwara, H.: Sequence-specific recognition and cleavage of telomeric repeat (TTAGG)n by endonuclease of non-LTR retrotransposon, TRAS1. Mol Cell. Biol. (2001) 21, 100-108.

12)     Kubo, Y., Okazaki, S., Anzai, T. and Fujiwara, H.: Structural and phylogenetic analysis of TRAS, telomeric repeat-specific non-LTR retrotransposon families in lepidopteran insects. Mol. Biol. Evol, (2001) 18. 848-857.

13)     Kojima, K, Kubo, Y. and Fujiwara, H.: Complex and tandem repeat structure in sub-telomere of crickets, T. taiwanemma. J. Mol. Evol, (2002) 54, 474-485.

14)     Takahashi, H. and Fujiwara, H.: Transplantation of target site specificity by swapping endonuclease domains of two LINEs. EMBO. J. (2002) 21, 408-417.

15)     Kojima, K. K. and Fujiwara, H.: Evolution of target specificity in R1 clade non-LTR retrotransposons. Mol. Biol. Evol, (2003) 20, 351-361.

16)     Kojima, K. K. and Fujiwara, H.: Cross-genome screening of novel sequence-specific non-LTR retrotransposons: various multicopy RNA genes and microsatellites are selected as targets. Mol. Biol. Evol. (2004) 21, 207-217.

17)     Matsumoto, T., Takahashi, H. and Fujiwara, H. Targeted nuclear import of ORF1 protein is required for in vivo retrotransposition of telomere-specific non-long terminal repeat retrotransposon, SART1. Mol. Cell Biol. (2004) 24, 105-122.

18)     Osanai, M., Takahashi, H., Kojima, K. K., Hamada, M. and Fujiwara, H.: Novel motifs in 3f-untranslated region required for precise reverse transcription start of telomere specific LINE, SART1. Mol. Cell Biol. (2004) 24, 7902-7913.

19)     Maita, N., Anzai, T., Aoyagi, H., Mizuno, H. and Fujiwara, H.: Crystal structure of the endonuclease domain encoded by the telomere-specific LINE, TRAS1. J. Biol. Chem (2004) 279, 41067-41076.

20)     Anzai T., Osanai, M., Hamada, M. and Fujiwara, H.: Functional roles of read-through 28S rRNA sequence in in vivo retrotransposition of non-LTR retrotransposon, R1Bm. Nucleic Acids Res. (2005) 33, 1993-2002.

21)    Kojima, K. K. and Fujiwara, H.: An extraordinary retrotransposon family encoding dual endonucleases, Genome Research, in press (2005)

22)     Matsumoto, T. Hamada, M. Osanai, M. and Fujiwara, H.: Essential domains for Ribonucleoprotein complex formation required for retrotransposition of a telomere specific non-LTR retrotransposon SART1. Mol. Cell. Biol. 26, 5168-5179 (2006)

23)    Ando, T., Fujiyuki, T., Kawashima, T., Morioka, M., Kubo, T. and Fujiwara, H.: In vivo gene transfer into the honeybee using a nucleopolyhedrovirus vector. Biochem. Biophys. Res. Comm. 352, 335-340 (2007)

24)     Kawashima, T., Osanai, M., Futahashi, R., Kojima, T. and Fujiwara, H.: A novel target-specific gene delivery system combining baculovirus and sequence-specific LINEs. Virus Research. 127, 49-60 (2007)

25)    Maita, N., Aoyagi, H, Osanai, M., Shirakawa, M. and Fujiwara, H.: Characterization of the sequence specificity of the R1Bm endonuclease domain by structural and biochemical studies. Nucleic Acids Research, 35, 3918-3927 (2007)

26)     Osanai-Futahashi, M. and Fujiwara, H.: Coevolution of telomeric repeats and telomeric-repeat-specific non-LTR retrotransposons in insects. Molecular Biology and Evolution. 28, 2983-2986 (2011)

27)    Fujiwara, H.: Site-specific non-LTR retrotransposons. Chapter 50 in gMobile DNA IIIh eds. by N. Craig et al., pp1147-1163. doi: 10.1128/9781555819217 (2015)

28)     Fujiwara, H.: Site-specific non-LTR retrotransposons. Microbiology Spectrum, 3(2). April doi: 10.1128/microbiolspec.MDNA3-0001-2014 (2015)

29)     Nichuguti Narisu, Hayase M. and Fujiwara, H.: Both exact target site sequence and long poly(A) tail are required for precise insertion of the 18S rDNA-specific non-long terminal repeat retrotransposon R7Ag. Mol. Cell. Biol36, 1494-1508. (2016)

 

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